A Viable Lyopreserved Amniotic Membrane Modulates Diabetic Wound Microenvironment and Accelerates Wound Closure

Sandeep Dhall, Tyler Hoffman, Malathi Sathyamoorthy, Anne Lerch, Vimal Jacob, Matthew Moorman, Jin-Qiang Kuang, and Alla Danilkovitch

VLAM

Study Summary

Chronic wounds, such as diabetic foot ulcers, are often characterized by persistent inflammation, oxidative stress, and poor vascularization, which delay tissue repair and regeneration. The objective of this study was to evaluate the effects of VLAM on the impaired wound microenvironment and wound closure in a diabetic (db/db) mouse model. By examining key indicators of wound healing, including inflammation, oxidative stress, granulation tissue formation, and neovascularization, this study provides novel insights into the therapeutic potential of VLAM for chronic wound healing.