Summary
Diabetic foot wounds are challenging to heal due to complications like infection, trauma, neuropathy, and vascular disease, with no standardized diagnostic or classification systems currently available. Exosomes, nanoscale vesicles involved in intercellular communication, play a critical role in vascular regeneration, tissue repair, and inflammation regulation in diabetic wound healing. This review highlights exosomes from various cellular origins, such as fibroblasts, stem cells, and immune cells, showcasing their therapeutic effects in promoting wound healing, reducing inflammation, and enhancing vascularization. Additionally, exosomes can be engineered to deliver targeted therapies, presenting a promising avenue for precision treatment of diabetic wounds.